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The GIP receptor adds a second incretin signal that supports insulin sensitivity and appetite regulation
Dopamine release and metabolism in the rat frontal cortex, nucleus accumbens, and striatum: a comparison of acute clozapine and haloperidol
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The greater magnitudes of bodyweight reduction seen in this trial, as well as the improvements in cardiovascular risk factors and glucose control, can have beneficial effects on health goals in clinical practice. In the STEP UP T2D trial, a higher semaglutide dose resulted in an average bodyweight reduction of 13.2%, compared to 10.4% for the standard dose and 3.9% for the placebo
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